Screening Tests – Cumulative Incidence of False Positives

It’s easy to think of medical tests as black and white. If the test is positive, you have the disease; if it’s negative, you don’t. Even good clinicians sometimes fall into that trap. Based on the pre-test probability of the disease, a positive test result only increases the probability by a variable amount. An example:

Tactless About TACT: Critiques Without Substance Should Be Abandoned

In May 2008, the article “Why the NIH Trial to Assess Chelation Therapy (TACT) Should Be Abandoned” was published online in the Medscape Journal of Medicine. The authors included two of our own SBM bloggers, Kimball Atwood and Wallace Sampson, along with Elizabeth Woeckner and Robert Baratz. It showed that the existing evidence on treating

Science under Siege

A new book, Science Under Siege: Defending Science, Exposing Pseudoscience addresses many of the issues near and dear to the hearts of SBM bloggers and readers. A compilation of some of the best writing from the last few years of Skeptical Inquirer magazine, it’s not only good reading but can serve as a useful reference.

AA is Faith-Based, Not Evidence-Based

Alcoholics Anonymous is the most widely used treatment for alcoholism. It is mandated by the courts, accepted by mainstream medicine, and required by insurance companies. AA is generally assumed to be the most effective treatment for alcoholism, or at least “an” effective treatment. That assumption is wrong. We hear about a few success stories, but

Re-evaluating Home Monitoring for Diabetes: Science-Based Medicine at Work

There is no question that patients on insulin benefit from home monitoring. They need to adjust their insulin dose based on their blood glucose readings to avoid ketoacidosis or insulin shock. But what about patients with non-insulin dependent diabetes, those who are being treated with diet and lifestyle changes or oral medication? Do they benefit

Celebrity Science

The current issue of Reader’s Digest has an article on “The Trouble with Celebrity Science.”  “What happens when stars weigh in on medical topics?…Celebrities may be perfectly qualified to evaluate sneakers, but that doesn’t mean you want to learn biochemistry from them.” They mention Tom Cruise’s sweeping condemnation of modern psychiatry, then focus on… Are you ready

Chiropractic in the News

Three recent news items about chiropractic have particularly irritated me. (1) U.S. Army Brigadier General Becky Halstead (Retired) Speaks Out for Chiropractic Care(2) Chiropractic Helps Child with Brain Disorder(3) Swine Flu Chiropractor’s Handout (1) General Halstead has become a spokesperson for The Foundation for Chiropractic Progress, a nonprofit organization dedicated to increasing public awareness of

Chiropractic’s Answer to Swine Flu: Get Adjusted!

Chiropractors are already capitalizing on people’s swine flu fears. This webpage http://www.planetc1.com/cgi-bin/n/v.cgi?c=1&id=1240864592  reproduces the text of a Swine Flu Handout chiropractors are giving their patients. It boils down to 6 recommendations: Build your immune system by getting adjusted. Limit the amount of sugar in your diet because sugar depresses the immune system. Avoid alcohol and

Acupuncture for IVF Revisited – More Tooth Fairy Science?

I read this Reuters Health article on MedlinePlus, and then I read the study the article referred to (The impact of acupuncture on in vitro fertilization) and now my head hurts. The study found that acupuncture was not effective in increasing the pregnancy rate (PR) during in vitro fertilization (IVF). As quoted on MedlinePlus, the lead author,

Is IV Sedation Over-Used?

We criticize alternative medicine for not being evidence-based, and they criticize conventional medicine in turn, saying that much of what conventional medicine does is not based on evidence either. Sometimes that criticism is justified. I have run across a conventional practice that I suspect began because it sounded like a good idea, but that never

Scroll to top