The polypill is effective for secondary prevention of cardiovascular disease. By combining drugs in a single pill, it improves convenience and compliance. The polypill, not polypharmacy. Polypharmacy is the use of multiple medications by a single patient, which is sometimes appropriate and necessary, but can be ill-advised and result in… read more "The Polypill Comes of Age"
Are you having trouble losing weight? So are a lot of other people. Have you tried intermittent fasting? Should you? According to a survey by the International Food Information Council, intermittent fasting was the most popular weight loss diet in 2018. Some have called it a fad whose adverse effects have… read more "Will Intermittent Fasting Help You Lose Weight?"
A useful review of all the current evidence about milk and health provides a lot of surprises. It shows that current recommendations are flawed and that much of what we have believed is wrong. Milk has been praised and vilified. Vegans eschew it. Babies thrive on it. Adults who are… read more "Milk and Health: The Evidence"
Naturopaths claim to excel at preventing and treating cardiovascular disease. Their claims don’t stand up to scrutiny. They co-opt from mainstream medicine, add non-evidence-based treatments, and fail to use effective drugs. The American Association of Naturopathic Physicians website explains what naturopathy is and has a webpage with FAQs. Number 15… read more "How Naturopaths Treat Heart Disease"
A couple of years ago, the James Randi Educational Foundation commissioned me to develop a series of 10 video lectures on Science-Based Medicine. After a lot of work and many vicissitudes, it is now available. The lecture titles are: Science-Based Medicine vs. Evidence-Based Medicine What Is CAM? Chiropractic Acupuncture Homeopathy Naturopathy and… read more "Announcing: Video Lecture Course on Science-Based Medicine"
Under the new blood pressure guidelines, more people are classified as having high blood pressure; but the treatment emphasis is on lifestyle changes, not medications. The American Heart Association and the American College of Cardiology recently released new guidelines for the diagnosis and treatment of high blood pressure. The highlights are reported here.… read more "New Blood Pressure Guidelines: Why Are Previously Normal BPs Now Classified as High Blood Pressure?"
The movie “Cholesterol: The Great Bluff” claims that we have been lied to: cholesterol doesn’t cause heart disease and statins are harmful. It is biased and misleading. The people interviewed in the movie are denialists who don’t accept the clear evidence for the role of blood cholesterol levels and the… read more "The Movie “Cholesterol: The Great Bluff” Is an Exercise in Denialism"
News reports suggest new drugs may replace statins. PSCK9 inhibitors are useful, but only along with statins in high risk patients not controlled on statins alone, or for patients who can’t tolerate statins. They’re not about to replace statins. PyMOL rendering of the structure of the PCSK9 protein. Are statins obsolete? Are… read more "“New vaccine replaces statins?” Not so fast!"
Some people are reluctant to take statins because they don’t benefit the majority of patients who take them. Actually, most drugs don’t benefit most of the patients who take them. Since we have no way of identifying those who will benefit, we are stuck treating the many to benefit the… read more "Most Patients Get No Benefit from Most Drugs"
A recent study attempted to quantify the association of ten dietary factors with deaths from cardiovascular disease and diabetes. Headlines about the study were misleading. How likely is bacon to kill you? I’ve been seeing differing headlines about a recent study: MDLinx said, “Bacon, soda and too few nuts tied… read more "Dietary Associations with Cardiovascular and Diabetic Mortality: “Bacon, soda, and too few nuts”?"