Kidney Cancer and Incidentalomas

Kidney cancer diagnoses are increasing but there has been no increase in mortality or rate of metastases. Kidney cancer is most often diagnosed as an incidental finding on a CT scan that was done for unrelated reasons. Treatment may not always be needed. In the February 1, 2019 issue of American Family Physician, there is an

How Do Doctors Learn to Diagnose, and Can Machines Learn to Do It, Too?

Siddhartha Mukherjee weighs in on how doctors arrive at a diagnosis and how computers can assist but not replace them. Is this the doctor of the future? Probably not. I am a big fan of Dr. Siddhartha Mukherjee, a cancer physician, researcher, and stem cell biologist who is also a phenomenally gifted writer and an unequaled

Uncertainty in Medicine

  Medicine is an uncertain business. It is an applied science, applying the results of basic science knowledge and clinical studies to patients who are individuals with differing heredity, environment, and history. It is commonly assumed that modern science-based doctors know what they are doing, but quite often they don’t know for certain. Different doctors

IOM Recommends Replacing CFS with SEID

Exertion intolerance Chronic fatigue syndrome (CFS) is a controversial diagnosis that has also been called myalgic encephalomyelitis (ME or ME/CFS), post-viral fatigue syndrome (PVS), chronic fatigue immune dysfunction syndrome (CFIDS), Iceland disease, “yuppie flu,” and many other names. A new report from the Institute of Medicine (IOM) says that none of those names really fit the disease

Diagnosis, Therapy and Evidence

When Dr. Novella recently wrote about plausibility in science-based medicine, one of our most assiduous commenters, Daedalus2u, added a very important point. The data are always right, but the explanations may be wrong. The idea of treating ulcers with antibiotics was not incompatible with any of the data about ulcers; it was only incompatible with

Diagnostic Dilemmas

Sometimes diagnosis is straightforward. If a woman has missed several periods and has a big belly with a fetal heartbeat, it’s pretty easy to diagnose pregnancy. But most of the time diagnosis is much more difficult. Alzheimer’s can’t be diagnosed for sure until the patient dies and you do an autopsy. If only we had