New Evidence for Chondroitin

Several previous studies showed chondroitin was ineffective for knee osteoarthritis, but a new study says it is as effective as celecoxib. There are reasons to be skeptical. The dietary supplements chondroitin and glucosamine, separately or in combination, have been widely used to treat the pain of osteoarthritis of the knee. But do they work? When

Glucosamine and Chondroitin: Do They Really Work?

Glucosamine and chondroitin are widely used for osteoarthritis pain. My daughter even gives them to her elderly horse. Their popularity is puzzling, since the evidence from scientific studies indicates that they don’t work. Wikipedia has a useful survey of the history, studies, criticisms, and systematic reviews ( It includes a long list of references. I

Glucosamine Update

Stick-and-ball model of the glucosamine molecule (from the Wikimedia Commons, image by Benjah-bmm27) Osteoarthritis, the “wear-and-tear” type of arthritis, affects a great many of us as we grow older. Knee pain is a common symptom. The diet supplements glucosamine and chondroitin have been proposed as a more “natural” treatment than pharmaceuticals, and they are components of

Knee Osteoarthritis: Thumbs Down for Acupuncture and Glucosamine

Osteoarthritis is the “wear and tear” kind of arthritis that many of us develop as we get older.  Cartilage becomes less resilient with age, collagen can degenerate, and inflammation and new bone outgrowths (osteophytes) can occur.  This leads to pain, crepitus (Rice Krispie type crackling noises with movement), swelling and fluid accumulation in the joints

Effectiveness of Glucosamine and Chondroitin for Osteoarthritis

TO THE EDITOR: This article repeated a common misconception about the Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), interpreting it as showing that the combination of glucosamine and chondroitin is effective for treating moderate to severe osteoarthritis.1 The study found that glucosamine and chondroitin, separately or in combination, were not more effective than placebo. Only one of

Glucosamine: The Unsinkable Rubber Duck

Glucosamine is widely used for osteoarthritis pain. It is not as impossible as homeopathy, but its rationale is improbable. As I explained in a previous post, Wallace Sampson, one of the other authors of this blog, has pointed out that the amount of glucosamine in the typical supplement dose is on the order of 1/1000th

Glucosamine Update: A New Study and a New Product

When I recently wrote about glucosamine, I discussed the evidence up through the New England Journal of Medicine study of 2006, which I thought was a pretty definitive study showing that neither glucosamine, chondroitin or a combination of the two was more effective than placebo.  Subsequent studies have continued to fuel the controversy. One 2007 study showed that glucosamine sulfate was better than

Does Glucosamine Really Work?

 Glucosamine and chondroitin, used separately or together, are among the more popular diet supplements. They are used widely for osteoarthritis, especially of the knee, and have been better studied than most other diet supplements. But do they really work? The journal of my medical specialty, American Family Physician, recently published an article about the use

Keeping an Eye on Alternative Medicine

In case you hadn’t noticed, snake oil is alive and thriving under the shield of alternative medicine. As the Baby Boomers approach retirement age and develop health problems, we can expect an even greater boom of quackery, pseudoscience, and misinformation. Even the most critically thinking scientist may think less critically when he’s sick. This column